when someone tells me their reply rate has dropped, i don't guess.
i run the four pillars in order: infrastructure, then targeting, then offer, then copy.
that's the logical lens.
the reason most people don't diagnose properly is they change all four at the same time.
if you change four variables simultaneously, you have zero attribution on which one fixed or broke the thing.
you've got to isolate.
PILLAR 1: INFRASTRUCTURE CHECK
if all five answers are yes, infrastructure is fine and you can move to pillar 2.
if any are no, fix that first and don't touch anything else.
PILLAR 2: TARGETING CHECK
if targeting is drifting, you'll see flat opens and dropping reply rates.